The Collagen IV Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Arresten, BRU, COL4A1, HANAC, and POREN1. This antibody recognizes Human, and Mouse antigen. The Collagen IV Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802.Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171.PJ Lein, J. Cell Biol., Apr 1991; 113: 417.EC Tsilibary, J. Biol. Chem., Dec 1988; 263: 19112 - 19118